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January 17, 2023

Vilnius University news article on the EMBO Installation Grant award // "Dr Patrick Pausch, research professor and group leader at the Vilnius University (VU) Life Sciences Center-European Molecular Biology Laboratory (LSC-EMBL) Partnership Institute (PI), has received a substantial European Molecular Biology Organisation (EMBO) Installation Grant (IG). According to Dr Pausch, the installation grant scheme is invaluable for young scientists establishing their laboratories."

November 18, 2021

ESRF spotlight on Patrick's contribution to nucleoside phosphorylase research (during PhD @ Bange lab, Marburg) //
"Diffraction data collected at beamline ID29 shine light on the activity of promiscuous thermostable nucleoside phosphorylases. New research shows how these enzymes can be used to diversify nucleoside analogues, granting access to potential new antiviral and anticancer compounds."

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November 22, 2021

CMN News article, featuring Patrick's contribution to mini CRISPR systems (during Postdoc @ Doudna lab, Berkeley) //

"CasΦ was first reported last year in an article in Science by researchers in Jennifer Doudna's and Jill Banfield's labs at the University of California, Berkeley. The team discovered CasΦ as a new member of the CRISPR-Cas arsenal that originates from the largest known bacteriophages. Characterisation revealed that CasΦ targets and cleaves bacterial, human and plant DNA and that it is only about half the size of Cas9, which make it a very attractive addition to the gene-editing toolbox. We interviewed joint-first authors Basem Al-Shayeb and Patrick Pausch PhD from Doudna's lab shortly after this work was published. Earlier this year, Patrick Pausch was joint-first author on a publication in Nature Structural and Molecular Biology, which reported the cryo-EM structures of CasΦ (Cas12j) in pre- and post-DNA-binding states. The other first author on this work was Katarzyna Soczek PhD, a postdoctoral fellow in Eva Nogales' lab, also at the Universiy of California, Berkeley."

July 16, 2021

Patrick arrives at Vilnius University to set up a new lab at a new institute:  The Vilnius University LSC - EMBL Partnership Institute for Genome Editing Technology. - Exciting!

In the picture: Virginijus Šikšnys, Patrick Pausch and Gintaras Valinčius

"VU Gyvybės mokslų centro padalinyje, EMBL Partnerystės institute, darbą pradeda naujai kuriamos grupės vadovas dr. Patrick Pausch.

Jo vadovaujama grupė kurs ir plėtos CRISPR-Cas molekulinius įrankius, taikomus žmogaus sveikatos ir biotechnologijų srityse. Į VU Gyvybės mokslų centrą dr. P. Pausch atvyksta iš University of California Berklyje, kur iki šiol kelis metus dirbo dr. Jennifer Doudna grupėje.
„Neabejoju, kad tiek vadovo, tiek naujos grupės narių patirtys reikšmingai praturtins mūsų centro mokslinių tyrimų kryptis genomo redagavimo srityje, prisidės prie tarpdisciplininių tyrimų plėtros bei skatins bendradarbiavimą tarp VU GMC ir EMBL mokslininkų. Linkiu kuo geriausios sėkmės naujai tyrimų grupei. Patrickai, sveiki atvykę į VU Gyvybės mokslų centrą!“ – džiaugėsi dr. Gintaras Valinčius, VU GMC direktorius."

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